The flood of protein structural Big Data is coming. With the belief that biotech researchers deserve powerful analysis engines to overcome the challenge of rapidly increasing computational demands, we are devoted to developing efficient protein structural alignment search algorithms to assist researchers as they push the frontiers of biological sciences and technology. Here, we present SARST2, an algorithm that integrates primary, secondary, and tertiary structural features with evolutionary statistics to perform accurate and rapid alignments. In large-scale benchmarks, SARST2 outperforms state-of-the-art methods in accuracy, while completing AlphaFold Database searches significantly faster and with substantially less memory than BLAST and Foldseek. It employs a filter-and-refine strategy enhanced by machine learning, a diagonal shortcut for word-matching, a weighted contact number-based scoring scheme, and a variable gap penalty based on substitution entropy. SARST2, implemented in Golang as standalone programs available at https://10lab.ceb.nycu.edu.tw/sarst2 and https://github.com/NYCU-10lab/sarst, enables massive database searches using even ordinary personal computers.
聯絡資訊: 語言教學與研究中心 黃小姐 #52754 E-mail: judyltrc@nycu.edu.tw ———————————— 1. Eligible Applicants: Students currently enrolled at National Yang Ming Chiao Tung University (including local students in both undergraduate and master’s programs, excluding those enrolled in executive master’s programs, as well as international students for whom English is not their native language).
2. Application Period: Applications must be submitted during the academic year of the examination (to align with the project timeline). Each student may apply once for the “BESTSET” and once for “Other English Tests” during their academic period.
‼️For those who have passed the English proficiency tests specified in the guidelines from January 1, 2025, to the December 10, 2025, applications must be submitted and verified at the office no later than December 10, 2025. Late applications will not be accepted. Applicants who cannot comply with the relevant regulations and schedule may have their applications rejected at the discretion of the receiving and reviewing units. ‼️For first-year undergraduate and master’s students admitted in Academic Year 2025, only tests taken between August 1, 2025 and December 10, 2025 will be accepted. Applications must be submitted and verified at the office no later than December 10, 2025. Late applications will not be accepted. Applicants who cannot comply with the relevant regulations and schedule may have their applications rejected at the discretion of the receiving and reviewing units. (For first-year master’s students who were undergraduate students of this university between January 1, 114 and July 31, 114, applications for tests taken during this period will be accepted, but proof of enrollment must be provided.)
3. Application Method: After completing and submitting the online form ( https://forms.gle/iDTHAa48LKbu12Wc6 ), applicants must bring their student ID card, the original and one copy of the test score report, and a copy of their personal bank account to the office for verification no later than December 10. (Please choose one of the following offices to visit:)
