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本院蘭宜錚教授於2024年1月26-27日 辦理2024 第十四屆國際綠色永續生物科技研討會。
綠色永續生物科技研發團隊，其成立宗旨為致力發展綠色永續生物科技，「綠色永續生物科技」為利用生物體（含動物，植物及微生物的細胞）來生產有用的物質或製程的改進、生物特性的改良、降低成本及創新物種的科學技術，進行對醫學、環境、農業食糧等不同範疇提出新技術與貢獻。近年更朝著降低汙染及對自然環境無害的方向發展，主要內容為能源和環境技術的研究開發，其中特別指出綠色化學就是化學與永續發展的結合，其方向發展應符合改善人類健康和保護生態環境的要求。強調生物科技與產業應用的相關性，將「學術」與「產學結合」，加速「生物科技產業化」與「生物產業科技化」，以培養兼具「生物科技」和「產業應用」專業能力之人才。
本次研討會將同時辦理第七屆綠色永續盃啤酒競賽，為愛好啤酒的夥伴們，提供一個競賽與交流的機會。
活動網址：https://sites.google.com/view/2024gsbs
蘭宜錚副教授研究團隊發表研究成果於 Bioresource Technology
連結網址：https://pubmed.ncbi.nlm.nih.gov/36252759/
Engineering photoautotrophic microorganisms to directly convert carbon dioxide into platform chemicals is an attractive approach for chemical sustainability and carbon mitigation. Here, an engineered cyanobacterium Synechococcus elongatus PCC 7942 was developed to produce succinic acid directly from ambient carbon dioxide. Inhibition of succinate dehydrogenase and glycogen synthase by CRIPSR interference increased carbon flux towards succinic acid. Dual inhibition of these two genes led to an 82% increase in titer. The resulting strain produced 4.8 g/L of succinic acid in a 28-days cultivation. However, cells after the 28-days cultivation became non-viable and cannot continue production. This issue was addressed by re-inoculation with fresh cells into the production medium. This strategy enabled continuous succinic acid accumulation, reaching a final titer of 8.9 g/L. This study provides a sustainable route to succinic acid directly from carbon dioxide and a potential method to overcome the low titer limitation of cyanobacterial-based bioproduction for practical applications.
