Single-cell transcriptomics reveal circulating skin-homing CLA+ CTSW+ cytotoxic CD4+ T cells contribute to relapse of psoriasis

柯泰名副教授研究團隊發表研究成果於Clinical and Translational Medicine

連結網址:https://pubmed.ncbi.nlm.nih.gov/41249858/

In summary, we identified a novel circulating skinhoming CD4+ T cell subset, CLA+ CTSW+ T cells, that may drive psoriasis relapse by persisting in circulation, exhibiting cytotoxicity, and engaging pathogenic immune cells via MIF and PGE2/EP2 signalling, promoting a proinflammatory, Th17-skewed milieu (Figure S10). These results provide potential targets for psoriasis relapse prevention.

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