- 培養國家與產業的生物資訊高階人才,近五年培育 90 位以上碩士以及 20 位以上博士
- 生物資訊成果及論文全國第一亞洲領先, 被引用數超過30,000次
- 成員超過 21 篇論文 SCI Highly Cited Paper(現有成員 12 篇)
- 多項國科會國家型計畫及國衛院計畫
- 中心及成員經費每年達超過 2500 萬
特色
國內第一個以生物資訊研究及應用開發為主的頂尖研究中心,創立目標以跨領域研究為主軸
沿革
- 2002 – 生物資訊中心與生物資訊研究所同時成立(台灣首創)
- 2011 – 第二期教育部頂尖計畫成立為院級中心
亮點
推動原則
- 基礎研究與應用研究並重
- 跨領域團隊建立
- 深化國際研究合作
- 創新創業人才培育
結構生物與藥物開發
系統生物及精準醫藥
大數據與人工智慧
拓展產學合作交流
重點方向:動態系統生物與精準醫療
四大主軸
- 大數據與人工智慧
- 結構生物與藥物開發
- 系統生物與精準醫藥
- 推展產學與社會貢獻
結構生物
- Huang, K. W.; Liu, T. C.; Liang, R. Y.; Chu, L. Y.; Cheng, H. L.; Chu, J. W.; Hsiao, Y. Y.* Structural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1. PLoS Biol 2018, 16, e2005653. PLoS Biol 2018, 16, e2005653.
- Morrell, T. E., Rafalska-Metcalf, I. U., Yang, H., & Chu, J. W. (2018). Compound Molecular Logic in Accessing the Active Site of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B. Journal of the American Chemical Society, 140(44), 14747-14752.
系統生物資訊
- Lin, C. Y., Lee, C. H., Chuang, Y. H., Lee, J. Y., Chiu, Y. Y., Lee, Y. H. W., Jong, Y. J., Hwang, J. K., Huang, S. H., Chen, L. C., Wu, C. H., Tu, S. H., Ho, Y. S., Yang, J. M.* (2019) Membrane protein-regulated networks across human cancers, Nature Communications, 10(1):3131.
- Kai-Yao Huang†, Tzong-Yi Lee*† († joint first authorship), Hui-Ju Kao, Chen-Tse Ma, Chao-Chun Lee, Tsai-Hsuan Lin, Wen-Chi Chang, Hsien-Da Huang*, 2019 Jan 8, “dbPTM in 2019: exploring disease association and cross-talk of post-translational modifications”, Nucleic Acids Research, Vol. 47(D1): D298-D308. (SCI, IF: 14.9; Ranking: 10/285=3.5% in BIOCHEMISTRY & MOLECULAR BIOLOGY)
- Chi-Nga Chow†, Tzong-Yi Lee† († joint first authorship), Yu-Cheng Hung, Guan-Zhen Li, Kuan-Chieh Tseng, Ya-Hsin Liu, Po-Li Kuo, Han-Qin Zheng, Wen-Chi Chang*, 2019 Jan 8, “PlantPAN3.0: a new and updated resource for reconstructing transcriptional regulatory networks from ChIP-seq experiments in plants”, Nucleic Acids Research, Vol. 47(D1): D1155-D1163. (SCI, IF: 14.9; Ranking: 10/285=3.5% in BIOCHEMISTRY & MOLECULAR BIOLOGY) (ESI Highly Cited Paper)
- Hsi-Yuan Huang, Yang-Chi-Dung Lin, Jing Li, Kai-Yao Huang, Sirjana Shrestha, Hsiao-Chin Hong, Yun Tang, Yi-Gang Chen, Chen-Nan Jin, Yuan Yu, Jia-Tong Xu, Yue-Ming Li, Xiao-Xuan Cai, Zhen-Yu Zhou, Xiao-Hang Chen, Yuan-Yuan Pei, Liang Hu, Jin-Jiang Su, Shi-Dong Cui, Fei Wang, Yue-Yang Xie, Si-Yuan Ding, Meng-Fan Luo, Chih-Hung Chou, Nai-Wen Chang, Kai-Wen Chen, Yu-Hsiang Cheng, Xin-Hong Wan, Wen-Lian Hsu, Tzong-Yi Lee*, Feng-Xiang Wei*, Hsien-Da Huang*, 2020 Jan 15, “miRTarBase 2020: updates to the experimentally validated microRNA–target interaction database”, Nucleic Acids Research, Vol. 48 (D1), D148-D154. (SCI, IF: 14.9; Ranking: 10/285=3.5% in BIOCHEMISTRY & MOLECULAR BIOLOGY) (ESI Highly Cited Paper)
藥物開發
- Jhih-Hua Jhong, Yu-Hsiang Chi, Wen-Chi Li, Tsai-Hsuan Lin, Kai-Yao Huang, Tzong-Yi Lee*, 2019 Jan 8, “dbAMP: an integrated resource for exploring antimicrobial peptides with functional activities and physicochemical properties on transcriptome and proteome data”, Nucleic Acids Research, Vol. 47(D1): D285-D297. (SCI, IF: 14.9; Ranking: 10/285=3.5% in BIOCHEMISTRY & MOLECULAR BIOLOGY)
精準醫學
- Yuxuan Pang, Zhuo Wang, Jhih-Hua Jhong, Tzong-Yi Lee*, 2021 March, “Identifying anti-coronavirus peptides by incorporating different negative datasets and imbalanced learning strategies”, Briefings in Bioinformatics, 22 (2), 1085-1095. (IF: 9.5; Ranking: 3/77=3.9%, BIOCHEMICAL RESEARCH METHODS)
跨領域:生物、醫學、資訊
- Chen, H. H.#, Hsueh, C. W.#, Lee, C. H.#, Hao, T. Y.#, Tu, T. Y., Chang, L. Y., Lee, J. C., Lin, C. Y.* (2023) SWEET: a single-sample network inference method for deciphering individual features in disease, Briefings in Bioinformatics, 24(2), bbad032. (IF: 9.5; Ranking: 3/77=3.9%, BIOCHEMICAL RESEARCH METHODS)
- Chung, C. H., Lin, C. Y., Chen, C. Y., Hsueh, C. W., Chang, Y. W., Wang, C. C., Chu, P. Y., Tai, S. K., Yang, M. H.* (2023) Ferroptosis signature shapes the immune profiles to enhance the response to immune checkpoint inhibitors in head and neck cancer. Advanced Science, 10(15):e2204514. (IF: 15.1; Rank: 24/342=7.0%, MATERIALS SCIENCE, MULTIDISCIPLINARY)